Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser and Ser
نویسندگان
چکیده
Louise Fritsche, Sabine S. Neukamm, Rainer Lehmann, Elisabeth Kremmer, Anita M. Hennige, Andrea Hunder-Gugel, Martin Schenk, Hans-Ulrich Häring, Erwin D. Schleicher, and Cora Weigert Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Tuebingen, Member of the German Center for Diabetes Research; Institute of Molecular Immunology, Helmholtz Center, Munich, Member of the German Center for Diabetes Research; and Department of General, Visceral and Transplant Surgery, University Hospital Tuebingen, Tuebingen, Germany
منابع مشابه
Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907.
The identity of specific serine phosphorylation residues of insulin receptor substrate (IRS)-2 and their impact on insulin signal transduction are largely unknown. Ser(675) and Ser(907) of mouse IRS-2 are adjacent to PI 3-kinase or Grb2 binding domains, respectively. Using monoclonal phosphosite-specific antibodies, we demonstrated the phosphorylation of both serines after stimulation of Fao he...
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It has been suggested that serine (Ser) phosphorylation of insulin receptor substrate-1 (IRS-1) decreases the ability of IRS-1 to be phosphorylated on tyrosine, thereby attenuating insulin signaling. There is evidence that angiotensin II (AII) may impair insulin signaling to the IRS-1/phosphatydilinositol 3-kinase (PI 3-kinase) pathway by enhancing Ser phosphorylation. Insulin stimulates NO pro...
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The function of insulin receptor substrate-1 (IRS-1), a keymolecule of insulin signaling, is modulated by phosphorylation at multiple serine/ threonineresidues.Phorbolesterstimulationofcells inducesphosphorylation of two inhibitory serine residues in IRS-1, i.e. Ser-307 and Ser-318, suggesting that both sites may be targets of protein kinase C (PKC) isoforms.However, in an in vitro systemusinga...
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